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DNA Replication (Updated)

Explore the steps of DNA replication, the enzymes involved, and the difference between the leading and lagging strand! This video is an update from our old DNA replication video with nearly the same script but added detail and improved art! See table of contents by expanding details.

Table of Contents:
00:00 Intro
0:11 Why do you need DNA replication?
0:27 Where and when?
1:12 Introducing key player enzymes
2:48 Initial steps of DNA Replication
4:04 Explaining 5′ to 3′ and 3′ to 5′
5:09 Showing leading and lagging strands in DNA replication

Video has a handout here:

Factual Reference:
OpenStax, Biology. OpenStax CNX. May 8, 2019 acarreira1125.10" target="_blank" rel="noopener">

***Further Reading Suggestions***

-More info about prokaryote vs. eukaryote DNA Replication? (Which video doesn’t go into) Check out the bottom of this page of the peer-reviewed, FREE OpenStax testbook: acarreira1125.10:2l3nsfJKmikern9295/DNA-Replication-in-Eukaryotes" target="_blank" rel="noopener">

-More detail about DNA replication, including the different types of polymerase? Check out this page of the peer-reviewed, FREE OpenStax textbook: acarreira1125.10:NEk9ll-3/DNA-Replication-in-Prokaryotes" target="_blank" rel="noopener">

-Check out this science paper that details how cancer drugs can work to stop DNA replication in cancer cells.

The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky’s certification and experience in teaching biology at the high school level. Learn more about our videos here:

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Our intro music designed and performed by Jeremiah Cheshire.

End music in this video is listed free to use/no attribution required from the YouTube audio library

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Hindi Subtitles Credit: Alisha Aggarwal

Some translated subtitles on our videos were translated by the community using YouTube’s community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.

We have videos dubbed in Spanish and Portuguese using an artificial voice via to increase accessibility. See our Amoeba Sisters en Español channel and Amoeba Sisters em Português

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